This is an interesting and difficult passage. Why would Jesus be so troubled that Judas would betray him? Was it merely Jesus contemplating his upcoming death, or was the Lord troubled that he'd be betrayed by one of his own disciples? I think it's both. Jesus loved Judas and was hurt to see him fall away.
As you read this passage, be thinking about your own life, acts of betrayal you have committed and acts of betrayal you have received. Where does the gospel fit into all of this? At the end of the day, we know that Jesus understands betrayal better than we ever will and, not only that, he has the only answer.